Frontotemporal dementia: Pathology of gait?
Identifieur interne : 000215 ( France/Analysis ); précédent : 000214; suivant : 000216Frontotemporal dementia: Pathology of gait?
Auteurs : Gilles Allali [Suisse, France] ; Bruno Dubois [France] ; Frederic Assal [Suisse] ; Elise Lallart [France] ; Leonardo C. De Souza [France] ; Maxime Bertoux [France] ; Cédric Annweiler [France] ; Francois R. Herrmann [Suisse] ; Richard Levy [France] ; Olivier Beauchet [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (complications), Alzheimer Disease (diagnosis), Alzheimer disease, Alzheimer's disease, Anatomic pathology, Disability Evaluation, Executive Function (physiology), Executive function, Female, Frontotemporal Dementia (complications), Frontotemporal Dementia (diagnosis), Frontotemporal dementia, Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (pathology), Gait disorder, Humans, Male, Models, Statistical, Motor control, Nervous system diseases, Neuropsychological Tests, Postural Balance (physiology), Psychomotor Performance (physiology), executive function, frontotemporal dementia, gait disorders, motor control.
- MESH :
- complications : Alzheimer Disease, Frontotemporal Dementia.
- diagnosis : Alzheimer Disease, Frontotemporal Dementia.
- etiology : Gait Disorders, Neurologic.
- pathology : Gait Disorders, Neurologic.
- physiology : Executive Function, Postural Balance, Psychomotor Performance.
- Aged, Aged, 80 and over, Disability Evaluation, Female, Humans, Male, Models, Statistical, Neuropsychological Tests.
Abstract
The main diagnostic criteria of the behavioural variant of frontotemporal degeneration (bvFTD) include neurobehavioral and dysexecutive syndromes, but not specific gait characteristics although strong relationship between gait and prefrontal functions are increasingly recognized. Accordingly, we tested the hypothesis that patients with bvFTD would have more gait changes than older healthy controls and demented patients with Alzheimer's disease (AD). Sixty subjects were included in the study: 19 with bvFTD, 19 with AD and 22 healthy controls. Mean values and coefficients of variation (CV) of stride time while just walking (i.e., single tasking) and while walking with backward counting (i.e., dual tasking) were measured using the SMTEC®‐footswitch system. Stride time, mean value, and CV were significantly increased in both patient groups compared with healthy controls during single task or walking alone (P < 0.001) and during dual tasking (P < 0.001). After adjusting for age, Mini‐mental examination, psychoactive drugs, gender, and history of previous fall, only the patients with bvFTD group was associated with an increase of CV of stride time during single walking (P < 0.001) and dual tasking (P < 0.001). These data suggest that gait instability during single and dual tasking could represent a supportive argument for bvFTD. In clinical practice, such a diagnosis should be at least considered in any demented patient with gait instability. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22927
Affiliations:
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ISTEX:BF9CC9F2DB96D70E8F79A8D4E91012682D5EE666Le document en format XML
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De Souza</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 610, La Salpêtrière Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Federation of Neurology, La Salpêtrière Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 610, La Salpêtrière Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Federation of Neurology, La Salpêtrière Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine and Geriatrics, Angers University Hospital, UPRES EA 2646, University of Angers, UNAM</wicri:regionArea><wicri:noRegion>UNAM</wicri:noRegion><wicri:noRegion>UNAM</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Francois R" sort="Herrmann, Francois R" uniqKey="Herrmann F" first="Francois R." last="Herrmann">Francois R. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-30">2010-04-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="731">731</biblScope><biblScope unit="page" to="737">737</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BF9CC9F2DB96D70E8F79A8D4E91012682D5EE666</idno><idno type="DOI">10.1002/mds.22927</idno><idno type="ArticleID">MDS22927</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer disease</term><term>Alzheimer's disease</term><term>Anatomic pathology</term><term>Disability Evaluation</term><term>Executive Function (physiology)</term><term>Executive function</term><term>Female</term><term>Frontotemporal Dementia (complications)</term><term>Frontotemporal Dementia (diagnosis)</term><term>Frontotemporal dementia</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (pathology)</term><term>Gait disorder</term><term>Humans</term><term>Male</term><term>Models, Statistical</term><term>Motor control</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Postural Balance (physiology)</term><term>Psychomotor Performance (physiology)</term><term>executive function</term><term>frontotemporal dementia</term><term>gait disorders</term><term>motor control</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Postural Balance</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Models, Statistical</term><term>Neuropsychological Tests</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Contrôle moteur</term><term>Démence d'Alzheimer</term><term>Démence frontotemporale</term><term>Fonction exécutive</term><term>Pathologie du système nerveux</term><term>Trouble de la marche</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The main diagnostic criteria of the behavioural variant of frontotemporal degeneration (bvFTD) include neurobehavioral and dysexecutive syndromes, but not specific gait characteristics although strong relationship between gait and prefrontal functions are increasingly recognized. Accordingly, we tested the hypothesis that patients with bvFTD would have more gait changes than older healthy controls and demented patients with Alzheimer's disease (AD). Sixty subjects were included in the study: 19 with bvFTD, 19 with AD and 22 healthy controls. Mean values and coefficients of variation (CV) of stride time while just walking (i.e., single tasking) and while walking with backward counting (i.e., dual tasking) were measured using the SMTEC®‐footswitch system. Stride time, mean value, and CV were significantly increased in both patient groups compared with healthy controls during single task or walking alone (P < 0.001) and during dual tasking (P < 0.001). After adjusting for age, Mini‐mental examination, psychoactive drugs, gender, and history of previous fall, only the patients with bvFTD group was associated with an increase of CV of stride time during single walking (P < 0.001) and dual tasking (P < 0.001). These data suggest that gait instability during single and dual tasking could represent a supportive argument for bvFTD. In clinical practice, such a diagnosis should be at least considered in any demented patient with gait instability. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><settlement><li>Paris</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name></noRegion><name sortKey="Assal, Frederic" sort="Assal, Frederic" uniqKey="Assal F" first="Frederic" last="Assal">Frederic Assal</name><name sortKey="Herrmann, Francois R" sort="Herrmann, Francois R" uniqKey="Herrmann F" first="Francois R." last="Herrmann">Francois R. Herrmann</name></country><country name="France"><noRegion><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name></noRegion><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name><name sortKey="De Souza, Leonardo C" sort="De Souza, Leonardo C" uniqKey="De Souza L" first="Leonardo C." last="De Souza">Leonardo C. De Souza</name><name sortKey="De Souza, Leonardo C" sort="De Souza, Leonardo C" uniqKey="De Souza L" first="Leonardo C." last="De Souza">Leonardo C. De Souza</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Lallart, Elise" sort="Lallart, Elise" uniqKey="Lallart E" first="Elise" last="Lallart">Elise Lallart</name><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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